As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.

Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser ...

Award Application budgets are not limited but must be commensurate with the scope of the proposed research. The maximum project period is five years.

Award Application budget is limited to $10.35 million in direct costs per year. The project period is five years.

Award Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years.

Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...

A robust immune response to viral infections may protect against more than just a runny nose or a cold sore—it might also stave off Alzheimer’s disease. In the May 30 Science Advances, scientists led ...

A cadre of T cells, originating in gut and fat tissue, resides in the brain. The cells sit in the subfornical organ, which surveils the blood. They affect food-seeking behavior by releasing interferon ...

To narrow down the number of scents needed for such a test, Li first ranked each of the 16 SST-ID and 40 UPSIT scents for their ability to distinguish PD/DLB from controls in three cohorts—the De Novo ...

Since February, the termination of some 2,482 grants worth $8.6 billion has shaken the scientific community, including AD researchers. Thanks to government databases and intrepid scientists tracking ...