Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular ...

Retinoblastoma is a childhood retinal cancer that occurs in approximately 6 of 100,000 live births, with 250 to 300 new cases per year in the United States and approximately 8000 worldwide. 1 ...

Treatment was initiated in 308 participants per group. At week 48, HIV-1 RNA levels of 50 copies per milliliter or higher were found in 5 participants (1.6%) receiving long-acting therapy and in 3 ...

Ibrutinib, a Bruton’s tyrosine kinase inhibitor, may have clinical benefit when administered in combination with bendamustine and rituximab and followed by rituximab maintenance therapy in older ...

Insomnia is common and frequently occurs with other disorders. First-line cognitive behavioral therapy with or without medication can produce rapid, sustained alleviation of insomnia symptoms.

Hairy-cell leukemia, a rare B-cell cancer driven by a BRAF mutation and manifesting with cytopenias and splenomegaly, is responsive to purine analogue chemotherapy and to BRAF inhibitors combined w ...

Corporatization” of health care, a process predicted decades ago, now refers to the general trend throughout the industry toward higher levels of integrated control by consolidated profit-seeking ...

The Race and Medicine collection reflects the commitmentfrom NEJM to understanding and combating racism as a public health and human rights crisis.

The authors examine the epidemiology, pathogenesis, clinical expression, and differential diagnosis of Behçet’s syndrome, as well as targeted therapeutics.

The lifetime risk of cardiovascular disease was 24% (95% confidence interval [CI], 21 to 30) among women and 38% (95% CI, 30 to 45) among men for whom all five risk factors were present. In the ...

Most rotator-cuff tears are degenerative, atraumatic, and more prevalent with age. Nonoperative treatment, including physical therapy, is typically recommended; surgery is considered in some cases.

The clinical aspects and implications of hearing loss in adults are presented, along with the current criteria for cochlear implantation. Modern cochlear-implant surgery and its pros and cons are d ...