Many models have been proposed to explain how and why trinucleotide repeats in the human genome can expand and cause disease. This Review re-evaluates such models in the light of our knowledge of ...

Examining trinucleotide repeats: Study cites implications for human disease. by Georgia Institute of TechnologyGeorgia Institute of Technology ...

“Trinucleotide repeat instability has been viewed largely as a matter of DNA metabolism; however, our data suggest that repeat instability may be influenced by aspects of polyQ protein toxicity. Thus, ...

Mol Cell. 2020 Jan 6. pii: S1097-2765(19)30923-2. doi: 10.1016/j.molcel.2019.12.010.[Epub ahead of print] Abstract. Bacteria possess an array of defenses against foreign invaders, including a broadly ...

The normal huntingtin gene contains up to 35 repeats of the trinucleotide CAG, encoding glutamine; the disease-causing form contains more than 35, up to and beyond 100 repeats. “The challenge is to ...

Huntington’s disease and Friedreich’s ataxia are part of a group of neurological disorders dubbed trinucleotide repeat disorders because they are caused by repeating three-letter stretches of DNA.

Trinucleotide repeats are simple repetitive sequences of 3 nucleotides that follow the pattern of CNG, where N can be any nucleotide. They can be found throughout the human genome, ...