来自台湾阳明大学，美国斯坦福大学等处的研究人员发表了题为“Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats”的文章，利用表型筛选和RNA测序等技术，发现了一种新型转录机制，为亨廷顿舞蹈症等具有同样氨基酸特征的神经失序症的治疗提出了新思路，这一研究成果公布在Cell杂志 ...

当基因的微小变动，足以颠覆一个人的命运，甚至引发无法逆转的脑部疾病时，我们该何去何从？三核苷酸重复序列（Trinucleotide Repeat, TNR）疾病 ...

Many models have been proposed to explain how and why trinucleotide repeats in the human genome can expand and cause disease. This Review re-evaluates such models in the light of our knowledge of ...

Mol Cell. 2020 Jan 6. pii: S1097-2765(19)30923-2. doi: 10.1016/j.molcel.2019.12.010.[Epub ahead of print] Abstract. Bacteria possess an array of defenses against foreign invaders, including a broadly ...

Maxwell received his Bachelor of Science in Biochemistry and Neuroscience from the University at Buffalo in May of 2022. During his undergraduate studies, he worked in the lab of Dr. Jennifer Surtees, ...

Examining trinucleotide repeats: Study cites implications for human disease. by Georgia Institute of TechnologyGeorgia Institute of Technology ...

Trinucleotide repeats are simple repetitive sequences of 3 nucleotides that follow the pattern of CNG, where N can be any nucleotide. They can be found throughout the human genome, ...

The normal huntingtin gene contains up to 35 repeats of the trinucleotide CAG, encoding glutamine; the disease-causing form contains more than 35, up to and beyond 100 repeats. “The challenge is to ...

“Trinucleotide repeat instability has been viewed largely as a matter of DNA metabolism; however, our data suggest that repeat instability may be influenced by aspects of polyQ protein toxicity. Thus, ...

Huntington’s disease and Friedreich’s ataxia are part of a group of neurological disorders dubbed trinucleotide repeat disorders because they are caused by repeating three-letter stretches of DNA.