One of the key challenges in artificial unisexual reproduction has been imprinting genes, which regulate developmental processes. Disruptions in these genes can cause embryos to fail in development.

In this groundbreaking study, researchers from the Chinese Academy of Sciences (CAS) detail how targeting a specific set of genes enabled them to bypass previously insurmountable barriers in unisexual ...

"These findings provide strong evidence that imprinting abnormalities are the main barrier to mammalian unisexual reproduction. This approach can significantly improve the developmental outcomes ...

Until now, many similar attempts have resulted in unhealthy offspring. "The unique characteristics of imprinting genes have led scientists to believe that they are a fundamental barrier to unisexual ...

The mouse survived to adulthood, marking a significant breakthrough in reproductive science. Their findings, published on January 28, 2025, in Cell Stem Cell, detail how they overcame longstanding ...

The experts targeted specific imprinting genes to overcome key barriers that previously prevented unisexual reproduction in mammals. More specifically, by modifying a set of genes involved in ...

This breakthrough is the result of years of research into overcoming the genetic barriers that prevent unisexual reproduction in mammals. Using advanced stem cell engineering techniques ...

“These findings provide strong evidence that imprinting abnormalities are the main barrier to mammalian unisexual reproduction,” Luo Guanzheng, co-corresponding author and a professor at Sun ...

"The unique characteristics of imprinting genes have led scientists to believe that they are a fundamental barrier to unisexual reproduction in mammals," says co-author Qi Zhou from CAS. "Even when ...

By modifying imprinting genes, researchers overcame previous barriers to unisexual mammalian reproduction. While only a small percentage of the engineered embryos survived to birth, the research ...

In contrast, mammals have strict genetic imprinting mechanisms that make unisexual reproduction extremely difficult. Unlike reptiles and fish, mammals require a precise balance of maternal and ...

This happens when certain maternal or paternal genes are shut down during development, and it is a fundamental barrier to unisexual reproduction in mammals. To address these limitations ...