Glioblastoma remains incurable and recurs in all patients. Here we design and characterize a novel induced-recurrence model in which mice xenografted with primary patient-derived glioma ...

SIL-204 administered in an extended release formulation reduced tumor growth by ~50% after 30 days, with ~50% of tumors showing complete necrosis, in human pancreatic tumors harboring a G12D mutation ...

This study provides a discovery that SUPR enhances the intra-tumour persistence of microparticles with a diameter of up to 5 μm, approximately, which we named as the micro-sized SUPR effect. Moreover, ...

Since microglia play a critical role in resolving amyloid pathology and it has been previously demonstrated that microglia function can be induced by TREM2 activation, TREM2 agonism has been ...

Since microglia play a critical role in resolving amyloid pathology and it has been previously demonstrated that microglia function can be induced by TREM2 activation, TREM2 agonism has been ...

Relative to xenografted control mice, or to ungrafted APP-KI mice, the APP-KI mice hosting human neurons had elevated p-tau181 and p-tau231 in their plasma. This suggested that, when faced with ...

Notable antitumor effects of ASP3082 have been demonstrated when intravenously administered weekly in mice xenografted with KRAS G12D-mutated cancer cells. Methods: This first-in-human, open-label, ...

Interferon alpha 2b (IFNA2b) has been used in immunotherapy for cancers with certain success. To reduce fast diffusion of IFNA2b and consequent dose-dependent side effects, we constructed a collagen ...

4058 Introduction: Carbonic Anhydrase IX (CAIX) is a transmembrane metalloprotease highly expressed in many hypoxic tumor types, thus representing an attractive diagnostic and therapeutic target.