Purpose: Men with diabetes have been found to have a reduced risk of prostate cancer (PCa), potentially due to detection bias from lower prostate-specific antigen (PSA) levels or inhibition of tumor growth. Understanding if lower PCa rates are due to a lower risk of the disease or a detection bias from PSA testing can help inform the benefits ...

2019年11月6日 · Preprescription PSA level and time between PSA tests were positively associated with PSA at follow-up, while CCI of 2 or greater was associated with lower PSA levels (eTable 2 in the Supplement). No discernible patterns were evident with respect to length of exposure for any antidiabetic medications, although a significant difference was seen ...

2008年5月1日 · In this study, we examined if serum prostate-specific antigen (PSA) levels are lower in men with type 2 diabetes compared with those in healthy men. Moreover, we investigated the relationships between serum PSA levels and serum androgen concentrations and investigated what factors may be associated with serum PSA levels in men with type 2 diabetes.

To examine the effects of type 2 diabetes mellitus (DM) on the variables associated with prostatic growth including serum prostate-specific antigen (PSA), serum testosterone, and prostate volume, and to correlate these variables with the duration of ...

2019年11月6日 · These seemingly contradictory findings could be explained by detection bias if diabetes medications lower prostate-specific antigen (PSA) levels and result in a delay in diagnosis. Alternatively, diabetes medications may modify the risk of …

2006年10月5日 · Our finding of a significant downward trend of PSA (from no diabetes to diabetes of more than 10 years' duration) is consistent with a possible association between progressing diabetes and decreasing testosterone concentrations, which may lower the risk of prostate cancer .

After adjusting age, significant PSA reductions were found in diabetic men, especially for men taking antidiabetics. Such association was seen when the diabetic status was represented by hemoglobin A1c (HbA1c) and fasting blood sugar (FBS) levels. That is, PSA levels were significantly reduced in men with higher HbA1c and FBS levels.

Men with type 2 diabetes have lower concomitant prostate-specific antigen (PSA) levels; however, the influence of metabolic conditions on PSA changes over time remains unknown. Therefore, the goal of this study was to assess associations between type 2 diabetes and hypertension and changes in serum PSA levels.

We found differences in the risk and characteristics of prostate cancer by diabetes status and that some risks have changed over time as guidelines have changed. With lower PSA use in the more recent time-period, rates of low-grade tumors have become more similar by diabetes status.

Several studies have shown an inverse association between diabetes mellitus and prostate cancer (PCa). Some researchers suggest that this relationship is due to reduced PCa detection in diabetics due to lower prostate-specific antigen (PSA) levels compared to non-diabetics.