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    https://en.wikipedia.org › wiki › Aflibercept

    Aflibercept - Wikipedia

    • Aflibercept, sold under the brand names Eylea and Zaltrap among others, is a medication used to treat wet macular degeneration and metastatic colorectal cancer. It was developed by Regeneron Pharmaceuticals. It is an inhibitor of vascular endothelial growth factor (VEGF). Aflibercept is a recombinant fusion protein consisting of the extracellular domains of hum… 展开

    Medical uses

    Aflibercept (Eylea) is indicated for the treatment of people with neovascular (wet) age-related macular … 展开

    Contraindications

    Aflibercept (Eylea) is contraindicated in people with infections or active inflammations of or near the eye, while aflibercept (Zaltrap) has no contraindications. 展开

    Adverse effects

    Common adverse effects of the eye formulation include conjunctival hemorrhage, eye pain, cataract, vitreous detachment, floaters, and ocular hypertension.
    Aflibercept (Zaltrap) has adverse effects typical of anti-ca… 展开

    Interactions

    No interactions are described for either formulation. 展开

    Mechanism of action

    In wet macular degeneration, abnormal blood vessels grow in the choriocapillaris, a layer of capillaries in the eye, leading to blood and protein leakage below the macula.
    Aflibercept (Zaltr… 展开

    Composition

    Aflibercept is a recombinant fusion protein consisting of vascular endothelial growth factor (VEGF)-binding portions from the extracellular domains of human VEGF receptors 1 and 2, that are fused to the Fc portion of the hu… 展开

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