The amygdala plays a central role in emotional processing and has an activating influence on the hypothalamic-pituitary-adrenal (HPA) axis. Structural changes in the amygdala have been associated with early adversity and, in principle, may contribute to the later emergence of emotional pathologies by influencing the way that the brain responds ...

2018年3月28日 · It plays a major role in regulating hormones, the pituitary gland, body temperature, the adrenal glands, and many other vital activities. Amygdala: the almond-shaped mass of nuclei involved in emotional responses, hormonal secretions, and memory.

The principal effectors of the stress response are localized in the paraventricular nucleus (PVN) of the hypothalamus, the anterior lobe of the pituitary gland, and the adrenal gland. This collection of structures is commonly referred to as the hypothalamic-pituitary-adrenal (HPA) axis ( Figure 1 ) .

Neuroimaging results indicated that both higher life trauma and low morning cortisol levels were associated with increased response to acute stress in limbic-medial temporal lobe (MTL) regions including the amygdala and hippocampus.

2017年7月5日 · We investigated the regulatory role of the amygdala upon the function of the hypothalamic-pituitary-adrenal (HPA) axis as measured by median eminence corticotrophin releasing hormone (CRH) content and serum levels of …

Bilateral lesions of the amygdala in rats reduced the adrenocorticotropin (ACTH) and corticosterone responses to electrical stimulation of the dorsal raphe nucleus, where the cell bodies of serotonergic neurons are located.

2023年10月26日 · The HPA axis, or hypothalamic-pituitary-adrenal axis, is a complex set of interactions between the hypothalamus, pituitary gland, and adrenal glands. It plays a critical role in regulating stress responses, mood, digestion, immune function, and energy storage and expenditure in the body.