关注公众号“医学科研小坑”，了解更多相关科研技术内容！ 白细胞分化抗原 （leukocytedifferentiation antigen，LDA）. 白细胞分化抗原（leukocytedifferentiation antigen，LDA）白细胞分化抗原：是白细胞（还包括血小板、血管内皮细胞等）在正常分化成熟不同谱系（lineage）和不同阶段以及活化过程中，出现或 ...

Characterization of the potential role of CD3 + CD19 + cells and functional changes among the human immunodeficiency virus (HIV), Mycobacterium tuberculosis (Mtb) and HIV‐Mtb coinfection groups compared to healthy controls (HCs).

2024年1月5日 · The majority of these T/B phenotypic lymphocytes (CD3+CD19+) show an origin of pro/pre B cells and distribute widely in mouse bone marrow, lymph nodes, spleen, and peripheral blood.

12月24日，艾博生物ABO2203（表达CD3/CD19双抗的mRNA）治疗自身免疫性疾病的IIT临床试验在Clinicaltrials.gov上注册。 该IIT临床在瑞金医院进行，计划入组26例自免患者， 包括但不限于系统性红斑狼疮、类风湿关节炎、系统性硬化症、特发性炎症性肌病等。

T细胞膜表面有100多种特异性抗原，现已制备了多种单克隆抗体，WHO（1986）统称为白细胞分化抗原（cluster differentiation，CD）。例如CD3代表总T细胞，CD4代表T辅助细胞（TH），CD8代表T细胞毒性细胞（TC）等。

2021年12月22日 · Validation of CD3 + CD19 + cells and functional changes among patients with human immunodeficiency virus (HIV), Mycobacterium tuberculosis (Mtb) and HIV-Mtb coinfection groups compared to healthy controls (HCs). (A) Eight surface markers (CD3, CD4, CD8, CD11b, CD19, CD45, CD56 and CD161) were used to construct a Visne map.

In this study, we describe a novel CD19/CD3/HSA-specific T cell-engaging antibody construct for the treatment of diverse B-cell malignancies expressing the B-cell lineage marker CD19. Target expression levels on cancer cells typically show a Gaussian distribution.

2021年1月19日 · Monocyte activation mediated by TNF-α generated by T-cell triggering has been demonstrated to be a primary source of systemic cytokine release after treatment with anti-CD3 × anti-HER2 ...

2025年2月10日 · The very first bi-specific T-cell engager (BiTE) approved by the food and drug administration (FDA) in 2014 was Blinatumomab, which presents binding sites for CD3 and CD19, and it has proven to be ...

2 天之前 · The numbers of CD45 + CD19 + B cells and CD45 + CD3 + T cells were individually 8.3 and 3.6 times higher than those in the PBS group (Fig. 4, D and E, and fig. S24). Therefore, many TLS were formed in tumor tissues of the ADU-S@M1 group ( …