Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. [5] [6] [7] [8] PECAM-1 plays a key role …

CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1), is a single chain 130 kDa glycoprotein consisting of 6 Ig-like extracellular domains, a short transmembrane segment and a cytoplasmic tail containing two ITIMs (ImmunoTyrosine Inhibitory Motif).

CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A. 2015;112:E5815–5824. doi: 10.1073/pnas.1509627112. This study builds importantly on the results of reference 65 to demonstrate that PECAM-1 ITIM signaling confers cytoprotection to the vascular endothelium exposed to pro-apoptotic stimuli.

CD31, or PECAM-1 (platelet endothelial adhesion molecule), is a cell-cell adhesion and signaling protein with established roles in immune cell transmigration and angiogenesis.

CD31, or platelet endothelial cell adhesion molecule-1 (PECAM-1) is a member of the Ig gene superfamily expressed at high density at the lateral borders of endothelial cells (ECs) and at a lower density on the surface of hematopoietic cells including T lymphocytes ().By establishing homophilic interactions between apposing ECs and between the endothelium and migrating …

2007年9月13日 · Dangerfield J, Larbi KY, Huang MT, Dewar A, Nourshargh S. PECAM-1 (CD31) homophilic interaction up-regulates α6β1 on transmigrated neutrophils in vivo and plays a functional role in the ability of α6 integrins to mediate leukocyte migration through the perivascular basement membrane.

2024年12月25日 · PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include Angiosarcoma and Hemangioma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is FCRL5.

2017年3月15日 · Using nine-color flow cytometry, we show that CD31 is highly expressed on CD34 + progenitors and stays high until the early double-positive stage (CD3-CD4 + CD8α + β-). After β-selection, CD31 expression levels become low to undetectable. CD31 expression then increases and peaks on CD3 high CD4 + CD8 + double-positive thymocytes.

CD31 or Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kDa cell adhesion molecule that is highly expressed on the surface of endothelial cells and to a lesser extent on a range of hematopoietic cells, such as platelets, monocytes, neutrophils and T-cell subsets.

2013年6月1日 · CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a transmembrane homophilic receptor that is expressed by endothelial cells (ECs), platelets, granulocytes, macrophages, dendritic cells (DCs), T- and B-cells and natural killer (NK) cells.