Ergonovine, also known as ergometrine and lysergic acid propanolamide is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. [6] [1] It can be used either by mouth, by injection into a muscle, or injection into a vein. [6]

Ergometrine is an ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Generic Name Ergometrine

Ergometrine (ergonovine) is a crystalline alkaloid extract of ergot that is commonly used in obstetric cases to induce tonic uterine contraction through its action on uterine smooth muscle.

Ergometrine functions by directly stimulating the uterine muscle, thereby increasing both the force and frequency of contractions. This mechanism of action facilitates uterine contractions, diminishes postpartum bleeding, and serves as a preventive measure against premature birth.

2024年11月8日 · Ergometrine (Ergometrina) generic is an ergot alkaloid, prescribed for post-partum and uterine bleeding. It helps the uterus contract back and prevents bleeding after childbirth.

Ergometrine is metabolised by CYP3A4; its adverse effects such as vasoconstriction may be increased if it is given with inhibitors of CYP3A4; avoid combinations including HIV Protease inhibitors.

Ergonovine (otherwise called ergometrine) is an ergot alkaloid acting as a serotonin agonist that induces vasospasm in patients affected by variant angina via a mechanism mediated by the hypersensitivity of the 1D serotonin receptor subtype in vascular smooth muscle cells.

Ergometrine is a medication that stimulates the uterus to contract, making it useful for preventing and treating postpartum hemorrhage. It acts as an agonist for α-adrenoceptors and dopamine receptors, and its effects are immediate when administered intravenously.

Ergometrine increases the amplitude and frequency of uterine contractions and uterine tone which in turn impedes uterine blood flow. Contraction of the uterine wall around bleeding vessels at the placental site produces haemostasis. Ergometrine also increases contractions of the cervix.

Ergometrine acts on three different types of receptors found on the walls of blood vessels and in the uterus. When ergometrine stimulates these receptors, the blood vessels constrict and, consequently, the uterus. Contractions help push out the placenta.