IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils. Fc receptors are also found on eosinophils , monocytes , macrophages and platelets in humans.

2023年8月28日 · IgE can augment Fc-mediated effector functions by engaging receptors on immune cells like monocytes, neutrophils, macrophages, eosinophils, basophils, and mast cells. IgE can also engage antigen-presenting cells to enhance antigen uptake and presentation.

IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions.

Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of which are mediated through its two Fc receptors, FcεRI and CD23 (FcεRII). IgE and its interactions with these receptors are therefore potential targets for therapeutic intervention, and …

The high-affinity receptor for IgE, FcεRI, as expressed by mast cells and basophils, consists of an IgE-binding α chain, in which the two extracellular domains bind IgE, a β chain, which spans the plasma membrane four times and functions as a signal amplifier 37, and two identical and largely intracellular γ chains 38.

Two well-known IgE receptors, the high-affinity FcεRI and low-affinity CD23, mediate the activities of IgE. Unlike other known antibody receptors, CD23 also regulates IgE expression, maintaining IgE homeostasis.

The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity.

IgE and its receptors. IgE antibody uses two identical light and heavy chains and the constant region has four domains (Cε1‐Cε4). The two antigen‐binding sites are formed by pairing of the variable region of light and heavy chains.

2014年3月14日 · IgE binds to IgE receptors on immune cells in the tissues and in the circulation. There are two receptors for IgE: the high-affinity Fc receptor for IgE (FcεRI) and the low-affinity Fc...

Immunoglobulin E binds to the high-affinity IgE receptor, Fc ε RI, and is subsequently expressed on the surface of a number of key inflammatory cells, including mast cells, basophils, and dendritic cells.