In organic chemistry, isothiocyanate is a functional group as found in compounds with the formula R−N=C=S. Isothiocyanates are the more common isomers of thiocyanates , which have the formula R−S−C≡N .

Each glucosinolate forms a different isothiocyanate when hydrolyzed. For example, broccoli is a good source of glucoraphanin, the glucosinolate precursor of sulforaphane, and sinigrin, the glucosinolate precursor of allyl isothiocyanate.

In order to identify phytochemical compounds that preserve the natural intestinal microflora and ensure pathogen strain growth inhibition, Kim and Lee evaluated the antimicrobial activity of phenethyl isothiocyanate (PEITC) purified from Sinapis alba seed oil against pathogenic Clostridium species .

Some vegetables contain precursors of isothiocyanates: allyl isothiocyanate (sinigrin), benzyl isothiocyanate (glucotropaeolin), phenethyl isothiocyanate (gluconasturtiin) and sulforaphane (glucoraphanin).

2011年9月1日 · Some target proteins have been identified, but in-depth searches with new techniques are needed to reveal novel targets. Site-directed mutagenesis and isothiocyanate structure-activity relationships will assist in determining the biological significance of …

2023年2月14日 · Sulforaphane is an isothiocyanate that has received a lot of attention. It is present in cauliflower and broccoli and in a lab has exhibited anticancer and antimicrobial properties.

2024年3月7日 · This comprehensive review aims to consolidate the current understanding of Moringa isothiocyanates, mainly 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate), comparing this compound with other well-studied isothiocyanates such as sulforaphane and phenyl ethyl isothiocyanates.

Phenyl ethyl isothiocyanate has emerged as a promising protective agent in the context of neurodegeneration, showcasing neuroprotective properties through its modulation of various molecular pathways associated with oxidative stress, inflammation, and apoptosis.

Some isothiocyanates derived from cruciferous vegetables, such as sulforaphane (SFN), phenethyl isothiocyanate (PEITC), and benzyl isothiocyanate (BITC), are highly effective in preventing or reducing the risk of cancer induced by carcinogens in animal models.

2024年3月1日 · This review focuses on three specific ITCs: phenylethyl isothiocyanate (PEITC), allyl isothiocyanate (AITC), and benzyl isothiocyanate (BITC) and a combination of these compounds forming the active principles of ANGOCIN® Anti-Infekt N (Angocin; film-coated tablets, Repha GmbH, Langenhagen, Germany), a therapy for managing inflammatory …