Adrenal insufficiency leads to diffuse symptoms, may become life-threatening (adrenal crisis), and requires glucocorticoid replacement therapy. Primary adrenal insufficiency leads to both glucocorticoid (cortisol) and mineralocorticoid (principally aldosterone) deficiency.

2024年12月21日 · Addison's disease is a rare condition that happens when the body doesn't make enough of some hormones. Another name for Addison's disease is primary adrenal insufficiency. With Addison's disease, the adrenal glands make too little of the hormone cortisol. Often, they also make too little of another hormone called aldosterone.

2023年8月17日 · Destruction or dysfunction of the adrenal cortex mainly causes glucocorticoid and mineralocorticoid deficiency. Primary adrenal insufficiency is also known as autoimmune adrenalitis or Addison disease. Adrenal insufficiency ranges from mild nonspecific symptoms to life-threatening shock conditions.

Mineralocorticoid deficiency Because mineralocorticoids stimulate sodium reabsorption and potassium excretion, deficiency results in increased excretion of sodium and decreased excretion of potassium, chiefly in urine but also in sweat, saliva, and the gastrointestinal tract.

2014年4月1日 · Primary adrenal insufficiency, or Addison disease, has many causes, the most common of which is autoimmune adrenalitis. Autoimmune adrenalitis results from destruction of the adrenal cortex, which...

Hypoaldosteronism is an endocrinological disorder characterized by decreased levels of the hormone aldosterone. Similarly, isolated hypoaldosteronism is the condition of having lowered aldosterone without corresponding changes in cortisol. [1] ( The two hormones are both produced by the adrenals.)

2020年11月24日 · Electrolyte profiles suggest mineralocorticoid deficiency or end-organ resistance, along with hyperkalemia, hyponatremia and metabolic acidosis associated with profound urinary salt loss. Renal and adrenal function is normal. The diagnosis is confirmed by the markedly elevated plasma aldosterone concentrations and plasma renin activity.

2018年8月20日 · Adrenal insufficiency (AI) is a disorder characterized by the failure of adrenocortical function resulting mainly in impaired secretion of glucocorticoids (GCs) only or of GCs and mineralocorticoids (MCs), hormones crucial for energy, salt and fluid homeostasis.

2023年5月17日 · Adrenal insufficiency occurs when the adrenal glands produce an insufficient amount of glucocorticoids or mineralocorticoids. Early detection of adrenal insufficiency can be difficult, although treatment is usually successful once it is initiated. Treatment is tailored to the underlying cause and, in most cases, lifelong treatment is necessary.

2023年7月10日 · Mineralocorticoid deficiency refers to decreased levels or functional impairment of the mineralocorticoid hormones. These hormones are produced by the adrenal glands and are responsible for maintaining sodium, potassium, and water balance in the body, along with the regulation of blood pressure.