olfactory receptor, protein capable of binding odour molecules that plays a central role in the sense of smell (olfaction). These receptors are common to arthropods, terrestrial vertebrates, fish, and other animals.

Remarkable advances in our understanding of olfactory perception have been made in recent years, including the discovery of new mechanisms of olfactory signaling and new principles of olfactory processing. Here we discuss the insight that has been gained into the receptors, cells, and circuits that underlie the sense of smell. Introduction

Olfactory receptors (ORs), also known as odorant receptors, are chemoreceptors expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants (for example, compounds that have an odor) which give rise to the sense of smell.

2024年1月30日 · Olfactory receptors (ORs) form the most important chemosensory receptor family responsible for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the class A G protein-coupled receptors (GPCRs).

2024年3月1日 · Olfactory receptors (ORs) demonstrate unique 3D structures and conserved motifs which are different from many class A G protein-coupled receptors (GPCRs). Many recent studies have demonstrated that ORs are abundant in nonolfactory tissues, which suggests that they play important physiological roles in many human diseases and disorders.

2009年10月2日 · Remarkable advances in our understanding of olfactory perception have been made in recent years, including the discovery of new mechanisms of olfactory signaling and new principles of olfactory processing. Here, we discuss the insight that has been gained into the receptors, cells, and circuits that underlie the sense of smell.

2009年10月2日 · Here, we discuss the insight that has been gained into the receptors, cells, and circuits that underlie the sense of smell. Remarkable advances in our understanding of olfactory perception have been made in recent years, including the discovery of new mechanisms of olfactory signaling and new principles of olfactory processing.

The olfactory epithelium includes several distinct cell types (Figure 15.5A). The most important of these is the olfactory receptor neuron, a bipolar cell that gives rise to a small-diameter, unmyelinated axon at its basal surface that transmits olfactory information centrally.

Odorant receptor proteins have seven membrane-spanning hydrophobic domains, potential odorant binding sites in the extracellular domain of the protein, and the ability to interact with G-proteins at the carboxyl terminal region of their cytoplasmic domain.

2009年10月2日 · Remarkable advances in our understanding of olfactory perception have been made in recent years, including the discovery of new mechanisms of olfactory signaling and new principles of olfactory processing. Here, we discuss the insight that has been gained into the receptors, cells, and circuits that underlie the sense of smell.