Addgene's collection of plasmids for the Ras pathway. Ras is a small GTPase and constitutively active Ras is the most common oncogene in human cancer.

2025年2月7日 · Understanding Ras signaling pathways provides insights into how cells communicate and respond to external stimuli. Mutations in Ras genes are among the most common genetic alterations in human cancers, making them critical targets for research and therapeutic intervention.

2014年10月22日 · The RAS proteins in turn signal through three alternative pathways to affect many downstream targets including TP53, RB1, and MTOR. Arrows represent activation signals, dotted "T" lines represent inhibitory signals.

2022年11月7日 · The RAS Initiative, a "hub and spoke" model, connects researchers to better understand and target the more than 30% of cancers driven by mutations in RAS genes. Includes oversight and contact information.

2021年7月8日 · What is the Ras signaling pathway? H-Ras, K-Ras and N-Ras are closely related proteins that are frequently mutated in human cancers. Specifically, they are different isoforms of small, guanosine triphosphatases (GTPases) that function as …

2021年7月23日 · The first two corresponding pathways, RAS–RAF–MEK–ERK and RAS–PI3K-AKT–mTORC, act as fundamental signaling pathways of RAS proteins . Mutations in the three RAS isoforms, G12, G13, and Q61, can abolish the intrinsic GTPase activity of RAS and increase the GEF-mediated exchange rate [ 27 , 28 , 29 ].

Ras proteins function as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways control processes such as actin- cytoskeletal integ­rity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration.

Frank McCormick, scientific lead of the RAS Initiative, incorporates over 30 suggestions from the RAS community to formulate an updated version of the RAS pathway, v2.0

2025年2月11日 · The RAS signaling pathway is intricately connected with other cellular signaling networks through cross-talk mechanisms. This interconnectivity allows cells to integrate and process multiple external stimuli, ensuring coordinated responses. One example involves the PI3K-AKT pathway, frequently co-activated in RAS-driven cancers.

The ras pathway is a crucial signaling cascade that begins with the activation of Ras proteins, which are small GTPases, and plays a significant role in regulating cell growth, differentiation, and survival.