The cardiomyocyte plasma membrane, termed the sarcolemma, is fundamental for regulating a myriad of cellular processes. For example, the structural integrity of the cardiomyocyte sarcolemma is essential for mediating cardiac contraction by forming ...

The sarcolemma (sarco (from sarx) from Greek; flesh, and lemma from Greek; sheath), also called the myolemma, is the cell membrane surrounding a skeletal muscle fibre or a cardiomyocyte. [1] [2] It consists of a lipid bilayer and a thin outer coat of polysaccharide material that contacts the basement membrane.

2015年4月10日 · In this review, we summarize recent developments that have uncovered specific protein complexes linked to mechanotransduction and mechanotransmission within the sarcomere, the intercalated disc, and at the sarcolemma.

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point upon which cardiac muscle contraction occurs.

2016年9月9日 · We review evidence for the involvement of sarcolemmal makeup changes in the impairment of stress‐resistance and cardioprotection observed with ageing and highly prevalent co‐morbid conditions including diabetes and hypercholesterolaemia.

2019年4月29日 · This review focuses on cardiac sarcolemma stability and its role as a therapeutic target in ischemia-reperfusion injury. Synthetic block copolymers have been shown to interface with the muscle membrane to confer membrane stabilization during stress.

2019年6月6日 · We demonstrate that SSPN ameliorated more advanced cardiac disease in the context of diminished sarcolemma expression of utrophin and β1D integrin, which mitigate disease severity, and partially restored responsiveness to β-adrenergic stimulation.

The cardiomyocyte plasma membrane, termed the sarcolemma, is fundamental for regulating a myriad of cellular processes. For example, the structural integrity of the cardiomyocyte sarcolemma is essential for mediating cardiac contraction by forming microdomains such as the t-tubular network, caveolae …

The sarcolemma is the specialized cell membrane of cardiomyocytes. It contains a multitude of muscle-specific and ubiquitously expressed membrane proteins that anchor the cytoskeleton and sarcomere to the surrounding extracellular matrix (ECM), allowing for the regulated exchange of ions and nutrients, as well as the activation of biomechanical ...

2019年9月13日 · The cardiomyocyte plasma membrane, termed the sarcolemma, is fundamental for regulating a myriad of cellular processes. For example, the structural integrity of the cardiomyocyte sarcolemma is essential for mediating cardiac contraction by forming microdomains such as the t-tubular network, caveolae and the intercalated disc.