The mTOR pathway is the body’s central hub for muscle growth and recovery. Protein intake, strength training, and hormonal signals all activate this pathway, telling your muscles to repair, rebuild, and grow stronger. Understanding how these factors work together can help you optimize training, nutrition, and long-term performance. | Dr Manjunath Sukumaran
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Insulin is a highly anabolic hormone in skeletal muscle, where it activates the PI3K/Akt/mTOR pathway to stimulate protein synthesis, enhance amino acid uptake, and inhibit proteolysis for net hypertrophy. It further suppresses muscle protein breakdown while promoting translation initiation through mTORC1 signaling. In bone tissue, insulin directly binds to receptors on osteoblasts, driving their proliferation, differentiation, and collagen production via MAPK and PI3K pathways. Overall, this le
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