med's go on Instagram: "Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by excessive erythrocyte production due to constitutive activation of the JAK-STAT signaling pathway. The JAK2 V617F mutation is present in over 95% of PV cases and leads to continuous erythropoiesis independent of erythropoietin (EPO) stimulation. This mutation occurs in the JAK2 gene, which encodes a tyrosine kinase involved in cytokine signaling. Unlike secondary polycythemia, where EPO levels are el