State the functions of mast cells in allergy response. - Biology | Shaalaa.com

Understanding Mast Cells and Their Role in Response to Allergens | Immunology

“Your allergy test was negative… so why do you still feel awful after eating certain foods?” This is a super common experience in people with mast cell activation syndrome (MCAS). Here’s the catch: not all food reactions are IgE-mediated (the kind allergy tests look for). Some foods can directly trigger mast cells to release histamine and other chemicals — no IgE antibodies involved. Plus, if you have histamine intolerance (a related condition), even healthy foods like tomatoes, spinach, aged ch