23K views · 208 reactions | Can high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels be used to predict cardiovascular risk over a long period of time? NEJM Editorial Fellow Sarah Gorey breaks down the Women’s Health Study in this 60-Second Journal Club. Full study: https://nej.md/3Mrh9A8 | The New England Journal of Medicine | Facebook

When you have lab work done and you check your high sensitivity C-reactive protein (Hs-CRP) it invariably comes with a chart that states your risk for a future cardiovascular event. Broken up into low, average and high. If LDL cholesterol is so predictive of heart disease and thus heart attack, why doesn’t it come with such a chart? That’s because LDL is a dependent variable that needs other factors to be present for it to be a risk factor whereas inflammation is an independent variable, it impl